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The receptor is a class B G-protein-coupled receptor that signals mainly through cyclic AMP, and it is expressed far beyond the pancreas, in the brain, gut, vasculature, heart, and kidney

BPC 157 enhanced the phosphorylation of Src, Cav-1 and eNOS which was abolished by pretreatment with Src inhibitor, confirming the upstream role of Src in this signal pathway

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